St Helens full-back Jonny Lomax has been ruled out for the rest of the season with the knee injury he sustained in Saturday's 42-0 defeat by Catalan Dragons.
The 23-year-old limped off in the second half of Saturday's First Utility Super League match in Perpignan and has been told he needs an operation.
That will remove any chance Lomax had of making England's end-of-season tour Down Under for the Four Nations Series.
He was included in England coach Steve McNamara's 34-man squad for a mid-season training camp in Loughborough at the weekend, which he was forced to miss.
Saints coach Nathan Brown said: "This is obviously a blow to the team but more importantly to Jonny. He has been in great form and has settled well into the full-back position.
"He will now begin his road to recovery led by our medical staff and we wish him well.
"Jonny has a strong character and we're sure he will come back and prove once again to be a pivotal player for us."
Lomax, who inherited the number one jersey from Paul Wellens at the start of the season, was making his first appearance since recovering from a minor knee injury which forced him to miss Saints' recent wins over Huddersfield and Salford.
Wellens, who has started matches at loose forward and in both half-back spots so far this season, is set to revert to his old full-back role for St Helens' home game against Castleford on Sunday.