All eyes will be on the Olympic Stadium later for the 100m showdown between British favourite Jonnie Peacock and the "Blade Runner" Oscar Pistorius.
The race promises to be one of the hottest contests of the Paralympic Games after both flew through their qualifiers last night.
Pistorius has been mired in controversy throughout the games after his claims following his 200m final loss to Brazilian Alan Oliveira. The South African claimed some competitors were being given an advantage by having longer prosthetic legs.
And the row deepened on Wednesday after the South Africa team claimed others were changing their legs between races, contravening games rules.
Peacock, from Cambridge, is the fastest Paralympian in the world and set a blistering pace through his heat - setting up a tantalising final.
Cyclist Sarah Storey, 34, is bidding to become a games legend as she aims to match Baroness Tanni Grey-Thompson's British female record of 11 Paralympic gold medals. On Wednesday, she won her third title of the games in the road race time trial at Brands Hatch in Kent.
Storey, who was born with a partly formed left hand, added the gold to her two in the 500m time trial and pursuit in the velodrome and will make it four if she wins the road time trial.
David Weir, 33, is looking to make it into the triple crown club as he goes for gold in the 800m final. He will also take part in Sunday's marathon on London's streets, and is favourite to make it a clean sweep of quadruple gold.
And Hannah Cockroft - who calls her wheelchair Sally - will be lining up to win her second gold as she races in the 200m. The 20-year-old, from Halifax, smashed the Paralympic record on her way to her previous win in the 100m and will be hoping for a similar performance later.